Demonstrating Analytical Comparability in Analytical Development

14th February 2023 | 1:00pm EST / 10:00am PST / 6:00pm GMT / 7:00pm CET / 2:00am CST / 11:30pm IST | Santoshkumar Khatwani, Director Analytical Development at Sangamo Therapeutics and James Wilkinson, Vice President of Corporate Development at Refeyn |WATCH FOR FREE

The presentation will focus on challenges in analytical comparability for gene therapy products. In addition, orthogonal methods along with some of the common statistical analyses will be discussed.

Presented by Santoshkumar Khatwani, Director of Analytical Development at Sangamo Therapeutics

Santoshkumar is currently serving as a Director of Analytical Development at Sangamo Therapeutics. Santoshkumar received early education in India with Bachelor’s degree in chemistry followed by a Master’s degree in Organic chemistry. He then joined National Chemical Laboratory in Pune (India) and worked on synthesizing organic compounds for potential pesticide applications. Later he moved to the United States to pursue a doctoral degree (Ph.D.) in chemistry from the University of Kentucky where his research focused on designing biosensing systems and responsive biomaterials using genetically modified proteins. Furthermore, he joined the Department of Chemistry at the University of Minnesota to conduct Postdoctoral research in the development of chemical and enzymatic approaches for generating novel protein-DNA complexes.

Followed by James Wilkinson, Vice President of Corporate Development at Refeyn

James studied a BA in Natural Sciences followed by a PhD in protein chemistry at the University of Cambridge studying the biophysical properties of ankyrin repeat proteins. After a short postdoc he joined NanoTemper Technologies in Munich in 2012 when the company was in its infancy. As one of the first application and sales specialists he stayed for 6 years developing the technology, launching new products and ended up running the UK subsidiary with responsibility for the UK and global distributor businesses. After working for a number of other start up companies he joined Refeyn in 2019 as the Sales Director, now as VP of Sales and Customer Success. Refeyn are an Oxford spin out company and have recently developed a methodology called mass photometry to analyse biomolecules. James is focussed on introducing the technology globally and supporting our rapidly growing customer base.

Sponsored by Refeyn

Refeyn, the mass photometry pioneer, offers new capabilities to characterise the function, structural composition and dynamics of biomolecules. Refeyn instruments measure the mass of individual molecules directly in solution, quickly and simply revealing the true behaviour of molecules in near-native environments. The diverse applications of mass photometry include quantitative analysis of sample purity and homogeneity, biomolecular complex assembly and disassembly, the strength and kinetics of molecular interactions, and more. Refeyn was spun out of Oxford University in 2018 to make mass photometry available globally. Its technology has now been rapidly adopted across academia and industry, where it is transforming biomolecular characterisation. The TwoMP, Refeyn’s mass photometer, brings the technology into everyday laboratory life, enabling molecular measurements with unprecedented speed and simplicity. It uses proprietary technology to detect the light scattered by single molecules in solution, delivering label-free mass measurements over a broad mass range with high precision and exquisite sensitivity.

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