Endotoxin Detection Challenges Associated With The Development Of A Novel VLP

14th November 2023 | 10:00am EST / 7:00am PST / 3:00pm GMT / 4:00pm CET | Aleksandra Moleda, Senior Development Scientist at Allergy Therapeutics |BOOK FREE SEAT FOR THIS WEBINAR

Endotoxins, otherwise known as lipopolysaccharides (LPS), are non‑infectious pyrogens associated with the cell membrane structure of Gram‑negative bacteria. This presentation outlines endotoxin detection challenges encountered during the development of a novel virus-like particle (VLP). Furthermore, this presentation provides a review of current methodologies accepted within industry to measure both endotoxin (i.e., LPS) and non-endotoxin pyrogens (NEPs).

There is no specific endotoxin test for VLPs, but they can be problematic during downstream processing, so the focus of the webinar will be to discuss approaches to address endotoxins/pyrogens, including the testing. General benefits/limitations from a scientific/regulatory compliance for each endotoxin/pyrogen test will also be discussed.

Presented by Aleksandra Moleda, Senior Development Scientist at Allergy Therapeutics

Aleksandra holds a BSc (Hons) in Cell Biology from the University of Stirling and a MSc (Distinction) in Biomedical Sciences from the University of Glasgow. With a keen interest in Immunology, Aleksandra pursued a PhD in Medicine with the University of Dundee where she specialised in the development of novel virus-like particle (VLP) platforms. Following the successful completion of her PhD, Aleksandra worked to improve conventional kidney dialysis at Invizius. Since 2022, Aleksandra has been a Senior Development Scientist with Allergy Therapeutics (UK) Ltd and is currently working on the development of a novel immunotherapeutic vaccine (VLP Peanut) for the treatment of peanut allergic patients.

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