Validating rCR on a Microfluidic Platform: A Multi-Matrix Approach

This presentation will explore the integration of recombinant Cascade Reagents (rCR) with centripetal microfluidic technology. We will detail our multi-matrix approach for comparing LAL and rCR on different sample types and how we assessed performance metrics such as sensitivity, specificity, and reproducibility across diverse sample types. We also address key technical challenges and practical considerations encountered during this research. Finally, the results of the study will be presented.

Presented by Hayden Skalski, Life Sciences Product Application Specialist at Veolia

Hayden Skalski serves as the Life Sciences Product Application Specialist for Veolia’s Sievers Analytical Instruments product line, with a specialized focus on bacterial endotoxins testing (BET). With over 12 years of dedicated experience in endotoxin testing and Quality Control Microbiology within the pharmaceutical industry, Hayden has established himself as a recognized expert in the field, regularly presenting on advanced topics related to endotoxin testing methodologies and best practices.

Throughout his career, Hayden has held progressive roles at industry-leading organizations including Charles River Laboratories, Regeneron, and Novartis. In these positions, he demonstrated expertise in validating and executing complex method development protocols for endotoxin testing, delivering technical customer support, resolving critical testing challenges, and supporting high-volume pharmaceutical product testing operations. Hayden holds a Bachelor of Science degree in Biology from the University at Albany (SUNY).

Followed by a live Question and Answer session

Sponsored by Veolia

Veolia is a world leader in ensuring pharmaceutical water quality and regulatory compliance through advanced monitoring technologies. Its Sievers Instruments product line specializes in analyzers for total organic carbon (TOC), bacterial endotoxins, and rapid bioburden monitoring to meet regulatory requirements while advancing process understanding and control. With over 30 patents for water analysis technologies in Sievers products, Veolia enables pharmaceutical and biopharmaceutical manufacturers to achieve compliance, optimize processes, implement effective troubleshooting strategies, and advance sustainability goals with simpler, more efficient analytical testing solutions.